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Q&A With StockPal – 4DMedical (ASX:4DX)

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Q&A with StockPal - Andreas Fouras, Chief Executive Officer and Chief Technology Officer of 4DMedical (ASX:4DX)

Watch Andreas Fouras, Chief Executive Officer and Chief Technology Officer of 4DMedical (ASX:4DX) and Jared Sim, Editor-in-Chief and Co-Founder of StockPal in this engaging Q&A with the following questions:

0:00 – StockPal Introductions
0:10 – What is your business about?
0:44 – How did your company cope with the COVID-19 pandemic?
1:48 – How does the company make money?
2:32 – Who are your target customers?
3:16 – What is your firm’s competitive advantage?
4:18 – How are you currently engaging with your investors?

Visit 4DMedical’s website to learn more about their story: https://4dmedical.com/

Email editor@stockpal.asia if you are or represent a listed-company and is keen to be in our interviews.

Want to be on the list next time this company raises capital? Open an account with Fresh Equities and start exploring capital raises – freshequities.com

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Q&A With StockPal – Avecho Biotechnology Limited (ASX:AVE)

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Q&A with StockPal - Dr. Paul Gavin. Chief Executive Officer of Avecho Biotechnology Limited (ASX:AVE)

2020 was a year for reinvigorating Avecho Biotechnology Limited (ASX:AVE) – cementing Company’s the rebrand, a change in CEO and a consolidated portfolio of products. Here to speak in this Q&A with StockPal is the Chief Executive Officer, Dr. Paul Gavin.

0:10 – Could you summarise for me what you set out to achieve in 2020?
1:15 – Could you tell me quickly what TPM is and its unique point of difference?
1:58 – Why is TPM a potential game changer for this CBD industry?
3:12 – Tell me about your interest in injectable products too?
4:21 – What activities and priorities are ahead to clinically test and commercialise these offerings in 2021?
5:29 – How did Avecho cope during the COVID-19 pandemic?
6:30 – How are you currently engaging with your investors/shareholders?

Visit Avecho’s website to learn more about their story: http://avecho.com.au/

Email editor@stockpal.asia if you are or represent a listed-company and is keen to be in our interviews.

Want to be on the list next time this company raises capital? Open an account with Fresh Equities and start exploring capital raises – freshequities.com

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Medical cannabis company to commence clinical trials in early 2021

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Medical cannabis company to commence clinical trials in early 2021

ASX cannabis stocks are gaining momentum, stimulated by significant developments in the global regulatory environments in recent months.

On the cusp of a potential rerate is $29M capped Neurotech International Limited (ASX: NTI), a stock with imminent newsflow.

NTI is a medical cannabis company focused on the clinical applications of unique cannabis strains to treat neurological disorders.

The last month has been an extremely rewarding period for the company, with stage 1 clinical product formulation and development studies commencing in mid-November, and an outlook to enter into clinical trials in the March quarter of 2021.

Management has also been able to report that further preliminary results of in-vitro human brain cell studies using its proprietary DOLCE/NTI leads, indicated that they can regulate multiple neuronal pathways that are directly involved in cell repair and rejuvenation.

This followed successful preliminary results of in-vitro studies in human neuronal cell studies, positioning the clinical product development program to optimise and develop the most suitable product for phase 1 clinical trial program.

The significance of the group’s achievements hasn’t been missed by investors with the company’s shares surging 130% to a high of 6.6 cents in the last fortnight, a level it hasn’t traded at for more than two years.

Global acceptance of cannabis growing

Neurotech’s recent success in this high profile industry has been driven by both individual and broader factors, as well as the company’s capacity to service high volume markets.

Clinical studies are assessing the neuro-protective, anti-inflammatory and neuro-modulatory activities of its proprietary DOLCE/NTI cannabis strains which include CBDA, CBDP and CBDB.

The strains are unique in that they contain minimal THC (<0.3%), which may result in a less onerous regulatory pathway to commercialisation (any cannabis strain with a THC level above 0.3% is regulated as a narcotic).

These developments are occurring during a time of increasing medical recognition of the benefits of medical cannabis in treating neurological conditions and assisting with mental health problems.

Regulatory authorities are also undergoing increased acceptance of the benefits of CBD, such that previous restrictions that made the drug difficult to access have been lifted and/or eased in many global jurisdictions, including the US, Canada, the European Union and indeed Australia.

This has prompted analysts to revisit forecasts regarding the industry’s growth profile in coming years, with such significant global developments rousing these numbers to increase further.

A significant drain on government health systems, both in human resources and the cost of development and supply of devices for neurological disorders suggests that regulatory bodies will increasingly embrace new technologies that are safe, efficient and less taxing on public medical services.

Neurotech to also benefit from home-based device boom

In addition, Neurotech is also commercialising Mente, the world’s first home therapy that is clinically proven to increase engagement and improve relaxation in children on the autism spectrum with elevated Delta band brain activity.

This therapeutic technology in home element is particularly interesting in light of the success of numerous ASX-listed and global enterprises that have met the demand for home use services and devices due to mobility restraints resulting from COVID.

Mente uses personalised audio feedback and earphones to gently guide the brain into a more relaxed state.

It is a soft, easy to use and portable headband that was developed to help those on the autism spectrum better self-regulate attention and mood, which has been based on autism research and a successful clinical trial.

Mente’s daily 40-minute sessions are personalised to the user’s current brain activity and have been designed to minimise any disruption to their daily routine, allowing them to continue with quiet activities (reading, drawing, school work etc) whilst still receiving therapeutic benefits.

This makes Mente perfect for use both at home and within an educational setting.

DOLCE/NTI leads more effective than use of CBD alone

Further data has demonstrated the potential uniqueness of the DOLCE/NTI leads in their mode of action and their differentiation when compared to CBD alone.

Neurotech has been collaborating with high profile medical research organisations in completing in-vitro human brain cell studies using its proprietary DOLCE/NTI cannabis leads, with subsequent results proving very promising.

The studies, conducted at Monash University, University of Wollongong and RMIT University are assessing the neuro-protective, anti-inflammatory and neuro-modulatory activities of the proprietary DOLCE/NTI cannabis leads which include, CBDA, CBDP and CBDB.

Studies have indicated that the DOLCE/NTI leads regulate multiple neuronal pathways which are directly involved in cell repair and rejuvenation.

These leads indicate significant increased potency in repairing neuronal cells when compared to CBD alone.

More importantly, concentrations five times lower of the DOLCE/NTI leads are needed to achieve these results when compared to CBD alone (2ug/ml versus 10ug/ml respectively).

DOLCE/NTI leads work through a novel (different to CBD) mechanism, and they were shown to work through the powerful anti-inflammatory enzyme known as Arginase-1.

Conversely, CBD alone did not produce any significant anti-inflammatory properties.

DOLCE/NTI leads also increased the presence of beta-tubulin, an essential protein in the maintenance and healthy survival of brain cells, while CBD did not produce an increase.

Beta-tubulin is a vital protein in the management of a number of chronic neurological disorders such as Alzheimer’s, Huntington’s and Multiple Sclerosis.

Final in-vitro results expected in coming weeks

Neurotech is positioned well to finesse its upcoming clinical program, selecting the optimum dose and patient parameters.

Commenting on the highly promising results as well as pointing to the potential for applications in other areas, Leedman said, “These preliminary trial results continue to be very encouraging, in particular the unique mode of action of our strains compared to CBD alone.”

“These results indicate that the DOLCE/NTI leads may have a broader application in relation to the management and treatment of a number of neurological disorders”.

Even with significant stock price upturn over the past month, there is potential for further share price moment as final in-vitro trial results are imminent.

The transition to clinical trials from preliminary tests is a major milestone, providing share price rerating’s as well as being the source of positive news flow throughout the trial process.

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Creso Pharma ready to take on recreational cannabis market as purchase orders mount up

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Creso Pharma ready to take on recreational cannabis market as purchase orders mount up

Last week, Creso Pharma Limited’s (ASX:CPH; FRA: 1X8) wholly-owned Canadian cannabis cultivation subsidiary, Mernova Medicinal Inc. received three purchase orders with a combined value of C$275,023 (A$288,159).

These new purchase orders are part of a trend this year, which has seen CPH generate more consistent revenue through product demand, whilst substantially trimming operating costs.

The first of the new purchase orders was valued at C$232,826 (A$243,841) and came from Truro Cannabis Company, a licensed producer of medical and recreational cannabis products.

The Truro order is a bulk order for three of Mernova’s high quality, indoor grown, hand trimmed, hang dried, cured, artisanal cannabis strains, in dried flower form, specifically HPG13, Lemon Haze and Mimosa.

Truro is well established throughout Canada, and will sell Mernova’s products via its well-established distribution channels.

Creso Pharma also received a maiden purchase order from the Yukon Liquor Corporation (‘Yukon’), opening a new Canadian market with the company anticipating further orders in the future.

The purchase order for the HPG13, Lemon Haze and Mimosa strains, in dried flower form is valued at C$24,333 (A$25,436).

These products will be sold under the Ritual Green brand in 3.5 gram and 7 gram units, through leading retailer Triple J’s Canna Space.

A Notice to Purchase from the Province of Ontario, also marks Creso’s entry into Canada’s largest recreational cannabis market.

These developments serve as confirmation of the significant demand for Mernova’s high-quality cannabis products in the rapidly growing Canadian retail recreational market.

This has been evident since October, when Creso announced that repeat purchase orders totalled more than $2 million on a year-to-date basis following a repeat purchase order from South African-based Pharma Dynamics.

In Europe, CPH continues to sell its CBD products in the animal health market via its Swiss operations, with a total of A$975,000 in Purchase Orders confirmed in 2020.

Total purchase orders continue to grow across CPH’s operations.

Commenting on these recent developments and expressing his confidence regarding the likelihood of further strong order flow, Mernova managing director Jack Yu said, “Mernova continues to make very strong progress in the Canadian recreational market.

“The three most recently secured purchase orders will contribute to Creso Pharma’s growing revenue profile and we expect additional orders to materialise in the very near term.

“Mernova has now become part of a very select group of licensed producers with cannabis products for sale in the Yukon.

“This is a major achievement for us, and we expect growth to continue across Canada and, with our pending entry into Ontario, Canada’s largest recreational market, we expect rapid growth to continue.”

Recreational markets across the globe could open up

Legal recreational marijuana has been available in Canada for two years now, however it looks as though other nations are following suit.

Last Friday, the US House of Representatives passed the Marijuana Opportunity Reinvestment and Expungement (MORE) Act – an Act that intends to decriminalise cannabis on a national level.

The decision is expected to have far reaching effects on the cannabis industry in North America, encouraging investors and corporate America to fully unlock the value of a multi-billion dollar industry, expected to surge to $130BN by 2024.

Mernova, Creso’s 24,000 sq.ft cannabis growing facility in Canada is only 1,700 miles from the US border.

Creso is now exploring near term opportunities for entry into the US recreational cannabis space right now, in readiness for legalisation. It is being assisted by Canadian cannabis icon Bruce Linton, who has come to Creso as a Strategic Advisor.

Mr Linton was the founder and CEO of Canopy Growth (TSX: WEED | NYSE: CGC), which he built from a tiny start up into a US$15BN market cap powerhouse at its peak.

Given these developments, CPH is currently trading at levels not seen since February 2020, prior to COVID sending global markets tumbling.

Looking globally, the United Nation’s Commission for Narcotic Drugs voted to reschedule cannabis, effectively removing it from a list including ‘hard’ drugs, such as heroin.

Furthermore, the Court of Justice of the European Union (CJEU) ruled that member states must not prohibit the marketing of lawfully produced CBD and ruled that CBD is not considered a narcotic.

As a result, CBD can be freely sold in the European Union (EU).

Even Australia is getting on board.

The Therapeutic Goods Administration (TGA) will shortly bring down its final decision regarding a major regulatory change in the distribution of cannabidiol (CBD) products in Australia.

The changes recommend that CBD products be down scheduled from schedule 4 and classified as schedule 3 medicines in Australia, which would allow Australian consumers to purchase CBD products over-the-counter (OTC) through pharmacies without the requirement of a prescription.

That announcement may already be paying off for Creso, which late last week announced it has secured an exclusive Heads of Agreement with leading natural, sustainable health and lifestyle brand supplier Martin & Pleasance Pty Ltd.

Under the agreement, Creso will manufacture a range of cannabidiol products in Switzerland, which would be sold under new and existing Martin & Pleasance brands in Australia.

Martin & Pleasance was established over 150 years ago and provides an extensive range of natural remedies and medicines to consumers.

Four products are earmarked from Creso’s proprietary nutraceutical range in lozenge and tea form, which are all manufactured at the GMP Certified Mernova facility.

With regulations around cannabis opening up across the globe, and well established global operations, Creso Pharma looks well placed for growth.

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